RNAi Drug for Cholesterol | MIT Technology Review

See on Scoop.itIB Biology

RNA interference shows promise in reducing cholesterol in animals.

jlinzel‘s insight:

Right behind the last story, the use of RNS inhibition. These are small single stranded RNA molecules that hybrdize [meaning they make mRNA double stranded inside a cell – they match up to form a double stranded RNA molecule] with mRNA in the cell. The dsRNA is often identified by the cell by a number of proteins that digest the dsRNA destroying the original mRNA in the process. So what you ask? What if the protein coded by the original mRNA is a transcription factor turning a gene on/off improperly? [gene regulation/expression topic of the IB objectives]. In summary, some mutations cause proteins to regulate other genes incorrectly. The mRNA for the mutated protein needs to be destroyed. Deliver a RNAi molecule to make the mutated mRNA double stranded. Cellular proteins notice the dsRNA [RNAi molecule + mRNA mutant] and destroys it. 

See on www.technologyreview.com

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s